Shandling did one of the first scripted shows on HBO, the Larry Sanders Show. It was about a make believe late night talk show and mixed drama with comedy in a way that would have scared off most comedians. It was also so original that it should not be forgotten. I went on YouTube and got the finale of the show and I am going to provide a link to it. If you don't know much about him, watch the show and if you know him well, watch the show and remember him.
YouTube - Larry Sanders Show S6 S11 Flip Series Finale